CDAO

From Evolutionary Informatics Working Group
Revision as of 16:37, 11 March 2008 by Arlin.stoltzfus@nist.gov (talk) (Test Data Sets)
Jump to: navigation, search

Comparative Data Analysis Ontology

The material previously on this page has been moved to CDAOManuscript.

This page is for ongoing work and contains links to supporting docs, past work, and sub-topics.

Test Data Sets

Each data set comes with a tree and a character matrix. The data are given in NEXUS format. The NESCent wiki does not like for us to upload XML, but if you want to get NeXML translations of these NEXUS files, they are available at Rutger Vos's [NEXUS-to-neXML conversion server].

There are four different categories of character sets:

  • cds: aligned nucleotides coded via IUPAC standard (T, C, G, A, and so on)
  • protein: aligned amino acids coded via IUPAC standard (A, C, D, E, F, G, H, I and so on)
  • continuous: numeric values of continuous characters (e.g., 0.001, 0.230)
  • morphology: discrete morphological characters with ad hoc numeric encoding (e.g., 0 = absent, 1 = present)

There are three grades of difficulty:

  • Simplified: small number of OTUs and characters; unambiguous states; single bifurcating tree
  • Typical: may contain many OTUs, multiple trees, polytomies, other stuff
  • Demanding: may contain ambiguous characters, mixed data types, notes, assumptions, etc.


type difficulty description comments NEXUS NeXML
CDS (DNA) Simplified Subset of 10 ATPase CDSs comments PF00137_10_cds.nex PF00137_10_cds.xml
CDS (DNA) Typical Cytochrome C CDS sequences comments PF00034_39_cds.nex PF00034_39_cds.xml
CDS (DNA) Typical Full set eukaryotic ATPase CDSs comments PF00137_47_cds.nex PF00137_47_cds.xml
CDS (DNA) Demanding NA comments [[Media:|NA]] [[Media:|NA]]
Protein (AA) Simplified Subset of 10 ATPase sequences comments PF00137_10_protein.nex PF00137_10_protein.xml
Protein (AA) Typical Full set eukaryotic ATPases comments PF00137_47_protein.nex PF00137_47_protein.xml
Protein (AA) Typical Cytochrome C family comments PF00034_39_protein.nex PF00034_39_protein.xml
Protein (AA) Demanding NA comments [[Media:|NA]] [[Media:|NA]]
Continuous Simplified NA comments [[Media:|NA]] [[Media:|NA]]
Continuous Typical NA comments [[Media:|NA]] [[Media:|NA]]
Continuous Demanding NA comments [[Media:|NA]] [[Media:|NA]]
Morphological Simplified NA comments [[Media:|NA]] [[Media:|NA]]
Morphological Typical NA comments [[Media:|NA]] [[Media:|NA]]
Morphological Demanding NA comments [[Media:|NA]] [[Media:|NA]]

Initial Implementation

Evaluation

Meeting Notes

Telecon, 7 March, 2007

present: Francisco Prodoscimi, Julie Thompson, Enrico Pontelli, Arlin Stoltzfus

What activities to do before the meeting? Plan for development?

  1. represent 4 simple test cases
    1. nt alignment plus tree
    2. prot alignment plus tree
    3. kinases with inhibitor sensitivity
    4. worm morphologies
  2. carry out operations with reasoning
    1. set and logic operations on characters and OTUs
    2. tree operations (clade selection, prune)
    3. other?
  3. map ontology to other representations
    1. NEXUS
    2. neXML
  4. start compiling list of concepts that are missing
    1. review Enrico's proposal
  5. look ahead to future challenges
    1. genetic encoding of characters
    2. ambiguous, multi-dimensional, or otherwise complex characters

Other issues for meeting and for paper

  • what is the scope?
  • How to integrate with other ontologies?
    • table from 'related artefacts' exercise
    • genetic code as a test case for integration
      • requires nt aa mapping to specify code
      • requires species taxonomy to assign code to species
      • requires cell ontology to assign code to compartmental genome (nuc, mito, cp)

Next meeting

  • telecon, 14 March, 2:00 pm UTC
  • agenda
    • nt and prot test data sets (arlin)
    • protege demo (brandon)

telecon, 14 March, 2:00 UTC

another meeting