Support for Evaluation

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Validation is a major problem in bioinformatics: how do we prove that a method is working within certain limits of accuracy; how do we determine if one method is better than another? Since most genome analysis is based on evolved data (i.e., comparisons), but natural standards are unavailable (e.g., we haven't evolved a new protein family in the lab so that we can use the data as a standard to test alignment and phylogeny programs), simulation is going to be a major tool for validation. What will be needed to support simulated standards used in validation? Can we develop target data sets for comparative evaluation?

Analysis of current challenges

Current status

(how is this need being met today? what resources, tools are available?)

Problems and projected difficulties

(what is missing? what challenges are coming up?)

Related or overlapping projects

(who else is working on this? what are they doing?)

Goals for the working group

(specific goals for this topic)

Strategy for achieving goal

(be sure to include specific deliverables or milestones)

Progress in achieving goals

(give dates and provide links to outputs)